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Those areas surrounding the Matias Hernandez River show a strong urban residential development as well as a commercial and industrial development at a much lower level. As characteristic in other areas in the city, residential developments surrounding the Matias Hernandez River do not pour their sewage into the closest sewer. Instead, they pour these into cesspools which eventually discharge into the river. This gets worse as the receiving sewer goes through residential areas and development and it has become an open ceiling garbage dump. The surrounding communities deposit all kinds wasted and garbage here which cause problems obstructing the river channel and flooding areas in certain section.In the other hand, if we observe the study fields of the research, we can see that it sticks to what in known as a “Regional Planning Unit”, “The Basin”. It refers to the Matias Hernandez River basin which cover about 2,500 hectares which harbors high concentrations of urban population from different social level. One of the most outstanding characteristics here is that the high, middle and low river channels develop entirely within the metropolitan area of the city of Panama.It is pertinent to point out that this study relates the effects of the population in their diversity of activities with the river, ecology, and water quality. This represents a model for the evaluation of a river water quality, but with a much wider and integral perspective which characterizes General Geography as a social science.