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Samples of water, sediment, and soft tissue of Leukoma asperrima were collected at three stations perpendicular to the water line at Bique Beach, Panama, to determine the concentration of trace metals copper (Cu), cadmium (Cd), and lead (Pb), at the low tide of syzygy between December and June 2021. The physical-chemical parameters were determined with a multiparametric probe, and the samples of the three matrices were collected and preserved until their treatment. Higher concentrations of copper and cadmium in water, lead in sediment, and copper in soft tissue was observed. Copper presented higher values in water in the dry season, while in sediment and soft tissue, it predominated in the rainy season, cadmium showed higher values in the rainy season in the three matrices, while lead concentration was higher in water and sediment. in the rainy season and the soft tissue, during the dry season. The values found for the three trace metals in L. asperrima tissue do not exceed the permissible limits for human consumption according to international standards.