The humanitarian crisis in various Latin American countries has generated in the migrant population a threat to mental health, known as Ulysses Syndrome. The objective of this review is to describe the epidemiological characteristics, the symptomatology of the Ulysses Syndrome in Latin American migrants and to identify the type of psychotherapeutic intervention most commonly used in the treatment. A documentary review was conducted, using the following search strategies: in relation to scientific databases with the selection criteria, which meet the two study variables and are elaborated from 2015 to 2020, in Spanish or English, in migrant populations, over 18 years of age, regardless of gender, who have been diagnosed with Ulysses syndrome; 110 articles were collected, of which only 53 were selected and the remaining ones were discarded. The results reflect the Ulysses syndrome as the clinical picture caused by the limit stress faced by migrants, the symptomatology is presented in the following areas: anxious, depressive, somatoform, personality, among others; scholars of this syndrome have suggested a multidisciplinary therapeutic intervention, with the participation of: physicians, educators, social workers, nurses; this therapy is aimed at enhancing the resilience of the immigrant, empowering him/her, teaching stress coping techniques and involving him/her in social support networks made up of migrants. It is concluded that this syndrome is part of the mental health conditions and that it should be diagnosed and treated in a timely manner.