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This essay presents an example of how the integration of knowledge is one of the most current methodological and epistemological demands in the field of education. It starts from the approach of essential aspects from a theoretical perspective: man, human activity and culture; as well as the emerging knowledge of postclassical rationality, such as Complex Thought, Ecosophy, Ecosophical Hermeneutics and its mediations, Bioethics, Second Order Epistemology and neurosciences. It is based on a very broad search for theoretical and methodological sources to achieve the systematization of the criteria of specialists in the paradigm shift towards complex thought. From the interpretation and reflection, it is concluded that a quality that characterizes human activity and the new emerging knowledge of thought is its integrative systemic character. The integration of knowledge comes from the natural and social reality in which it unfolds as a system, based on the interrelation between knowledge and knowledge; Furthermore, it is inherent to the holographic vision of everything that exists.
