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A seismic tomography of the Barú volcano and surrounding areas, in southwestern Panama, was carried out. The Barú volcano is one of the last volcanoes in the extreme south of Central America and the studies carried out in this research provide a very important scenario about its internal structure. Through seismic P-wave velocity tomography, images were obtained that show heterogeneities in the internal structure of the Barú volcano, which are due to the area's complex evolution, subduction and tectonics. The most important result is the negative anomaly to the northwest of the Barú volcano and southeast of Cerro Tizingal, present in all the layers, which could be related to a possible magmatic chamber. This study provides an overview of the possibilities of future eruptions, which will allow us to adopt more effective mitigation measures in the areas surrounding the Barú volcano where there is a population of around 20,000 inhabitants.