The concentration of heavy metals (copper and cadmium) in the gonadal tissue of Anadara tuberculosa was determined, in the Farfan estuary, located in the Montijo gulf, in six sampling stations, during six months, samples of Anadara tuberculosa were taken by collection Handbook. The state of sexual development could be identified through observations under a microscope and routine histology. For the gonadic cycle, a four-stage scale was used for both sexes: undifferentiated, development, spawning and reabsorption. The processing of the samples for the reading of trace metals was done by means of acid digestion and by graphite furnace atomic absorption spectrophotometry. The sexual ratio presented of females and males in the Farfan estuary was 1: 1. Copper presented a significant correlation in the concentration of metal between sexes. A significant difference occurred between the female index and the cadmium metal. There was a highly significant difference in the concentration of copper and cadmium in gonads between the two annual seasons (rainy and dry). The levels of heavy metals in gonadal tissue did not exceed the maximum permissible limits. It is recommended to monitor other areas of the Montijo gulf with the inclusion of other metals toxic to coastal ecosystems