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Weedy rice (Oryza spp.), a specific weed of cultivated rice, is one of the most damaging and important weeds in rice production systems worldwide. Its high genetic similarity to commercial rice makes its control challenging. This review examines the implications of weedy rice management, focusing on the evolution and spread of herbicide resistance. The introduction of imidazolinone-resistant rice (Group 2) (Clearfield® technology) initially offered effective control. However, over-reliance on this technology has led to the evolution of resistant weedy rice biotypes through gene flow and selection pressure, as documented in numerous countries. In response, the Provisia™ rice system, resistant to the ACCase-inhibiting herbicide quizalofop (Group 1), has been introduced as an alternative for controlling weedy rice and other weeds, primarily from the Poaceae family. This work emphasizes the sustainable management of this weed as a set of strategies that combine these technologies with crop rotation, diverse modes of action, and the reduction of the soil seed bank to decrease the evolution of herbicide resistance and ensure viability in rice production.