To find out the biometric relationships and gonadal development of the mangrove cockle Anadara tuberculosa, in Cate estuary, Gulf of Montijo, Panama, it was established six sampling stations collected manually each month from February to July 2017, the morphometrics characters were measured with a caliper and the weight with an analytic balance. The physicochemical properties were measured with a YSI multiparameter probe. The monthly growth was calculated by determining the length-frequency distribution and the modal analysis. A section of each gonad was extracted to determine the degree of maturity, based on a scale of four reproductive stages. The Sex Ratio was 1.06:1, the maximum spawning was in April coinciding with the maximum increase of salinity in the dry season. A. tuberculosa grew about 2.6 mm per month, the minimum length was 28.05 mm, and the highest 72.25, the weight varied between 10.5 to 126.2 g.