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The objective of this study was to determine the influence of environmental factors on the birth and weaning performance of Charolais cattle in the highlands of Chiriquí. A total of 1,880 individual production records were analyzed, encompassing information on birth weight (BW) and weaning weight adjusted to 205 days (WW205) from a farm located in the district of Tierra Altas. A mixed-effects model was employed to ascertain the fixed effects of birth year (2004-2018), birth season (dry, rainy), parity number (1,2...7), and calf sex (male, female) on the variables BW and WW205, with the dam considered as a random effect. In the case of WW205, BW was included as a covariate. Additionally, the level of correlation between BW and WW205 was assessed. The mean values obtained for BW and were 35.76 and 189.18 kg, respectively. BW was influenced (P<0.05) by sex and parity number, while WW205 was affected (P<0.05) by sex, parity number, and the weaning season. Finally, a correlation value of +0.28 was found between BW and WW205. It is concluded that environmental factors influence the growth performance of Charolais cattle and should be considered when making management and genetic improvement decisions in herds of this breed under the study conditions.