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A total of 16 gilts (158,158±3.5 kg) were assigned to one of two treatments to determine the effect of a Saccharomyces cerevisiae fermentation product (SCFP) supplementation during lactation on performance of sows and litters. The treatments were: CT) formulated to meet the nutritional requirements according to the National Research Council, NRC (2012); SCFP) similar to CT, plus 0.88% SCFP. Feed intake (FI) was recorded daily from farrowing until day 21 of lactation. At birth and on days 7, 14, and 21 of lactation, the weight of the litters was recorded to determine body weight gain (BWG), and milk samples were taken to determine the nutritional composition of the milk. The FI of the sows and the BWG of the litters were stratified into three phases with 7 days per phase [phase 1 (P1: d1-7); phase 2 (P2: d8-14); phase 3 (P3: d15-21)]. Blood samples were collected from the sows on days 7, 14, and 21 of lactation to determine the hematological profile. A treatment per day interaction was obtained in the FI, with a higher FI in sows fed SCFP during P1 and P2, with no differences in P3 (p<0.05). No differences were found in the BWG of the litters during lactation (p<0.05). Furthermore, there were significant differences in the treatment per day interaction for leukocyte concentration (p<0.05). Sows supplemented with SCFP had a higher percentage of milk fat compared to CT sows (p<0.05). In conclusion, SCFP supplementation stimulated sow feed intake, milk fat content and leukocyte profile of primiparous sows during lactation, without exerting productive improvements in litter performance.